Positive Darwinian selection in human population: A review
نویسندگان
چکیده
منابع مشابه
Hitchhiking under positive Darwinian selection.
Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present but rare, both deterministic and stochastic models of positive selection show that linked variation hitchhikes to either low or high frequencies. While the frequency distribution of variation can be i...
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The neutral theory of molecular evolution maintains that most sequence variation among genomes has no direct relevance to adaptation [1]. The rapidly-growing amount of genomic data makes it possible now to ask which proteins are undergoing adaptive evolution. This, in turn calls for better computational tools to detect positive selection. In this study, we present a new test for detecting posit...
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When Charles Darwin proposed the theory of evolution by natural selection, he was concerned with phenotypic evolution. Because all phenotypes have their genetic basis, natural selection indirectly acts on genotypes through its action on phenotypes. In this article, I review the roles of positive Darwinian selection in the evolution of genes, focusing on the work conducted in my laboratory in th...
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There are very few instances in which positive Darwinian selection has been convincingly demonstrated at the molecular level. In this study, we present a novel test for detecting positive selection at the amino-acid level. In this test, amino-acid replacements are characterized in terms of chemical distances, i.e., degrees of dissimilarity between the exchanged residues in a protein. The test i...
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Evolutionary mechanisms of origins of new gene function have been a subject of long-standing debate. Here we report a convincing case in which positive Darwinian selection operated at the molecular level during the evolution of novel function by gene duplication. The genes for eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) in primates belong to the ribonuclease gene f...
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ژورنال
عنوان ژورنال: Science Bulletin
سال: 2008
ISSN: 2095-9273,2095-9281
DOI: 10.1007/s11434-008-0202-z